Anaplastic ependymoma and atypical refractory longitudinal expansive transverse myelitis due to immune reaction after COVID-19 - a case discussion that raises many unknown questions about COVID-19.
Makaleler > Tam Makale · 2023
Yazarlar: Yağmur İnalkaç Gemici, Fatih Çelik, Zeynep Zerrin Göz, Aydın İşisağ, Gülgün Ovalı Yılmaz, Mehmet ZİLELİ, Mustafa barutçuoğlu, Hatice Mavioğlu
Archives of Neuropsychiatry, Uluslararası, Wos, 2023, cilt 61, ss 370-373
DOI: 10.29399/npa.28464
Özet
There are still many unknowns about the coronavirus disease that affected the whole world.Neurological complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19) are among these unknowns.Inflammatory neurologic manifestations, both infectious and non-infectious, have been reported secondary to COVID-19 (1).Dysregulated immune reaction due to parainfection may cause antibodymediated central nervous system (CNS) damage (2).In a review, authors reported 28/43 (70%) cases had longitudinally extensive transverse myelitis (LETM) (3).In the literature, there was no publication related to COVID-associated transverse myelopathy and spinal mass coexistence.In this case, such a patient will be reported and the relationship between COVID and mass will be discussed. CASEA 24-year-old woman admitted to our hospital with progressive weakness of the lower limbs, and bladder dysfunction for one month.Some members of her household were tested positive for SARS-CoV-2 three months ago.A few days later she developed similar symptoms to other family members.She was vaccinated with BNT162b2 (Pfizer-BioNTech) one month later.In her history, she had low back pain for one year and constipation for 4 months.Patient's cerebrospinal fluid COVID-19 antibody level was higher than serum and she was resistant to immunosuppressive treatment.The interaction between COVID-19 and spinal tumor was discussed in the light of the literature.It is thought that COVID-19 infection could trigger tumor growth in this patient.Also, this is the first case of anaplastic ependymoma and COVID-19 myelitis coexistence in the literature.