Development of gemcitabine-adsorbed magnetic gelatin nanoparticles for targeted drug delivery in lung cancer
Articles > Article · 2015
Authors: Şenay ŞANLIER, Merve Yasa, Asli Ozge Cıhnıoglu, Merve Abdulhayoglu, Habibe Yılmaz, Güliz AK DEMİROZ
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, Journal Indexed in SCI Expanded, International, 2015, vol 44, pp 1-7
DOI: 10.3109/21691401.2014.1001493
Summary
Magnetic iron oxide nanoparticles (IONPs) were coated with gelatin type B by means of the two-step desolvation method. Drug loading by adsorption was studied under various conditions such as different temperature, contact time, pH, and initial gemcitabine concentration. Further, Langmuir isotherm curves were constracted and constants were calculated. According to the Langmuir isotherm, the Gibbs free energy of the adsorption process at 25 degrees C was - 4.74 kJ/mol. On the other hand, this value at 37 degrees C was - 7.86 kJ/mol. In vitro drug release was performed at pH levels of 5 and 7.4, with gemcitabine-loaded magnetic gelatin nanoparticles and free gemcitabine, and both the results were subsequently compared.