Categorization of COPD patients in Turkey via GOLD 2013 strategy document: ALPHABET study
Makaleler > Tam Makale · 2015
Yazarlar: Hakan Gunen, MEHMET YILMAZ, PINAR ERGÜN, OĞUZ AKTAŞ, MEMDUHA GÖNENÇ ORTAKÖYLÜ, ATİKE DEMİR, PELİN ÇETİNKAYA, Alev GÜRGÜN, MÜGE OTLU, AYKUT ÇİLLİ, UFUK YILMAZ, NURDAN KÖKTÜRK, İPEK CANDEMİR, HALİL İBRAHİM YAKAR, İDİLHAN AR, AYLİN KONYA
International Journal of Chronic Obstructive Pulmonary Disease, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2015, cilt 10, ss 2485-2485
DOI: 10.2147/copd.s87464
Özet
OBJECTIVE: To determine distribution of COPD assessment categories and physicians' adherence to Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2013 strategy in Turkish COPD patients. METHODS: A total of 1,610 COPD patients (mean [standard deviation] age: 62.6 [9.9] years, 85.7% were males) were included in this multicenter, non-interventional, cross-sectional study. Patients were categorized via GOLD 2013 strategy document. Consistency between reported and re-classified GOLD categories, and measures used for symptom evaluation and exacerbation was analyzed. RESULTS: Overall, 41.1% of patients were assigned to GOLD A, while 13.2% were assigned to GOLD C categories. Long-acting beta-2 agonist + long-acting muscarinic antagonist + inhaled corticosteroid regimen was the most common treatment (62.0%). Over-treatment was noted in >70% of GOLD A, B, and C patients. A high consistency between measures of symptom evaluation (Kappa coefficient =0.993, P<0.0001) and a low-moderate consistency between exacerbation risk measures (Kappa coefficient =0.237, P<0.0001) were noted. CONCLUSION: Our findings revealed GOLD A as the most prevalent category in Turkish cohort of COPD patients. Group assignment was altered depending on the chosen measure for symptom and risk assessment. Physician non-adherence to treatment recommendations in GOLD 2013 document leading to over-treatment in patients assigned to GOLD A, B, and C categories was also detected.