Initial Basal and Bolus Rates and Basal Rate Variability During Pump Treatment in Children and Adolescents.
Makaleler > Tam Makale · 2021
Yazarlar: Günay DEMİR, Yasemin Hande ATİK ALTINOK, Samim ÖZEN, Şükran DARCAN, Damla Gökşen
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2021, cilt 13, ss 198-203
DOI: 10.4274/jcrpe.galenos.2020.2020.0171
Özet
Objective: Pump-treated children with type 1 diabetes (T1DM) have widely differing basal insulin (BI) infusion profiles for specific periods of the day. The pattern of BI requirements depends on the timing and magnitude of cortisol and growth hormone secretion within each age group. In adolescents and young adults, a decreased insulin sensitivity is seen, particularly in the early morning (dawn phenomenon) and to a lesser extent, in the late afternoon (dusk phenomenon). Different approaches exist for the inititation of basal rates. However, there is a lack of evidence-based recommendation, especially in young children. Usually the basal rates are set equally throughout day and night or the day is divided into tertiles. The aim of this study was to analyze the change of the initial, equally distributed, BI rates over the first year of standard insulin pump therapy.