Multicenter Analysis of Gestational Trophoblastic Neoplasia in Turkey
Makaleler > Tam Makale · 2014
Yazarlar: Sabit Sinan Ozalp, Elcin Telli, Tufan Oge, Gokhan TULUNAY, Nurettin BORAN, Taner TURAN, Mufit YENEN, Zehra Kurdoglu, Ali Ozler, KUNTER YÜCE, Volkan ULKER, Macit Arvas, Fuat Demirkiran, Tugan Bese, Nedim Tokgozoglu, Anil Onan, Muzaffer SANCI, Mehmet GOKCU, Gokhan TOSUN, Yilmaz DIKMEN, Ahmet Aydın ÖZSARAN, Mustafa Coşan TEREK, Levent AKMAN, Hakan YETIMALAR, Derya Sakarya KILIC, Tayfun GUNGOR, Emre OZGU, Yunus YILDIZ, Arif Kokcu, Mehmet Kefeli, Serkan Kuruoglu, Hasan Yuksel, Tevfik Guvenal, Pinar Solmaz Hasdemir, Bulent Ozcelik, Serdar Serin, Mehmet Dolanbay, Dagistan Tolga Arioz, Nadire Tuncer, Hasan Bozkaya, Suleyman Guven, Deniz Kulaksiz, Fusun Varol, Ali Yanik, Gonca Ogurlu, Tayyup Simsek, Tayfun Toptas, Selen Dogan, Hakan Camuzoglu, Murat API, Kadir GUZIN, Eray Caliskan, Emek Doger, Bulent Cakmak, Tolgay Tuyan Ilhan
Asian Pacific Journal of Cancer Prevention, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2014, cilt 15, ss 3625-3628
DOI: 10.7314/apjcp.2014.15.8.3625
Özet
BACKGROUND: To evaluate the incidence, diagnosis and management of GTN among 28 centers in Turkey. MATERIALS AND METHODS: A retrospective study was designed to include GTN patients attending 28 centers in the 10-year period between January 2003 and May 2013. Demographical characteristics of the patients, histopathological diagnosis, the International Federation of Gynecology and Obstetrics (FIGO) anatomical and prognostic scores, use of single-agent and multi-agent chemotherapy, surgical interventions and prognosis were evaluated. RESULTS: From 2003-2013, there were 1,173,235 deliveries and 456 GTN cases at the 28 centers. The incidence was calculated to be 0.38 per 1,000 deliveries. According to the evaluated data of 364 patients, the median age at diagnosis was 31 years (range, 15-59 years). A histopathological diagnosis was present for 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66) and 4.7% (n=17) of the patients, respectively. Regarding final prognosis, 352 (96.7%) of the patients had remission, and 7 (1.9%) had persistence, whereas the disease was mortal for 5 (1.4%) of the patients. CONCLUSIONS: Because of the differences between countries, it is important to provide national registration systems and special clinics for the accurate diagnosis and treatment of GTN.