Antimicrobial photodynamic therapy against Staphylococcus aureus using zinc phthalocyanine and zinc phthalocyanine-integrated TiO2 nanoparticles
Makaleler > Tam Makale · 2019
Yazarlar: Ayca Tuncel, Ismail Ozturk, Mine Ince, Kasim Ocakoglu, Mine HOŞGÖR LİMONCU, Fatma YURT
Journal of Porphyrins and Phthalocyanines, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2019, cilt 23, ss 206-212
DOI: 10.1142/s1088424619500238
Özet
Antibiotic resistance is an increasing healthcare problem worldwide. In the present study, the effects of antimicrobial photodynamic therapy (APDT) of ZnPc and ZnPc-integrated TiO2 nanoparticles (ZnPc-TiO[Formula: see text] were investigated against Staphylococcus aureus. A light emitting diode (LED) (630–700 nm, 17.4 mW/cm[Formula: see text] was used on S. aureus at different light doses (8 J/cm2 for 11 min, 16 J/cm2 for 22 min, 24 J/cm2 for 33 min) in the presence of the compounds under the minimum inhibitory concentration values. Both compounds showed similar phototoxicity toward S. aureus when high light doses (16 and 24 J/cm[Formula: see text] were applied. In addition, the success of APDT increased with an increasing light dose.