99mTc-Exorphin-glucuronide in tumor diagnosis: Preparation and biodistribution studies in rats
Articles > Article · 2006
Authors: TÜRKAN ERTAY, Perihan ÜNAK, O ÖZDOĞAN, Fazilet Zümrüt BİBER MÜFTÜLER, Figen ZİHNİOĞLU, E. I. Medine, HATİCE DURAK
Journal of Radioanalytical and Nuclear Chemistry, Journal Indexed in SCI Expanded, International, WoS, 2006, vol 269, pp 21-28
DOI: 10.1007/s10967-006-0226-2
Summary
A glucuronide derivative of exorphin C called exorphin C glucuronide was obtained by enzymatic synthesis and labeled with Tc-99m using glucoheptonate (GH) as bifunctional chelating agent. Labeling efficiency was 99.7 +/- 0.03%. Biodistribution studies were performed on normal and mammary tumor bearing albino Wistar rats. In addition, scintigraphic imaging with Tc-99m-GH-exorphin C glucuronide (Tc-99m-GEG) was performed. The radiopeptide-glucuronide is rapidly cleared via the urinary system showing lower liver uptake. Results demonstrated that Tc-99m-GEG can be used as a vehicle to target tumors.