Patient-Specific quality control applicator in gynecological Brachytherapy: Design, Production, and dosimetric evaluation

Makaleler > Tam Makale · 2026

Yazarlar: Yusuf Ziya HAZERAL, Burçin Hazeral, Nezahat OLACAK, Senem ALANYALI, Zeynep ÖZSARAN

Physica Medica, SCI İndekslerine Giren Dergi, Uluslararası, Wos, 2026, cilt 142, ss 105749-105749

DOI: 10.1016/j.ejmp.2026.105749

Özet

<p>Introduction:&nbsp;This&nbsp;study&nbsp;aims&nbsp;to&nbsp;design&nbsp;and&nbsp;manufacture&nbsp;a&nbsp;novel&nbsp;Multi-Channel&nbsp;Vaginal&nbsp;Cylinder&nbsp;(MCVC)&nbsp;applicator&nbsp;capable&nbsp;of&nbsp;performing&nbsp;patient-specific&nbsp;quality&nbsp;control.&nbsp;The&nbsp;applicability&nbsp;and&nbsp;dosimetric&nbsp;performance&nbsp;of&nbsp;the&nbsp;applicator&nbsp;were&nbsp;evaluated.</p><p>Methods:&nbsp;Several&nbsp;tests&nbsp;were&nbsp;conducted&nbsp;to&nbsp;assess&nbsp;the&nbsp;water&nbsp;equivalence&nbsp;of&nbsp;the&nbsp;designed&nbsp;applicator&nbsp;in&nbsp;terms&nbsp;of&nbsp;Hounsfield&nbsp;Units&nbsp;(HU),&nbsp;structural&nbsp;homogeneity,&nbsp;and&nbsp;dose&nbsp;transmission&nbsp;for&nbsp;192Ir&nbsp;relative&nbsp;to&nbsp;water.&nbsp;Dosimetric&nbsp;&nbsp;evaluations&nbsp;were&nbsp;performed&nbsp;using&nbsp;calibrated&nbsp;thermoluminescent&nbsp;dosimeters&nbsp;(TLDs)&nbsp;to&nbsp;determine&nbsp;the&nbsp;clinical&nbsp;&nbsp;&nbsp;&nbsp;usability&nbsp;of&nbsp;the&nbsp;applicator.&nbsp;No&nbsp;patients&nbsp;were&nbsp;involved&nbsp;in&nbsp;the&nbsp;dosimetric&nbsp;tests;&nbsp;all&nbsp;measurements&nbsp;were&nbsp;conducted&nbsp;in&nbsp;a&nbsp;water&nbsp;phantom.</p><p>Results:&nbsp;According&nbsp;to&nbsp;the&nbsp;HU&nbsp;examination&nbsp;results&nbsp;of&nbsp;the&nbsp;designed&nbsp;and&nbsp;manufactured&nbsp;applicator,&nbsp;it&nbsp;was&nbsp;ascertained&nbsp;that&nbsp;the&nbsp;structure&nbsp;was&nbsp;homogeneous,&nbsp;and&nbsp;the&nbsp;results&nbsp;obtained&nbsp;in&nbsp;terms&nbsp;of&nbsp;water&nbsp;equivalence&nbsp;were&nbsp;superior&nbsp;in&nbsp;comparison&nbsp;to&nbsp;those&nbsp;achieved&nbsp;by&nbsp;the&nbsp;Nucletron&nbsp;applicator.&nbsp;In&nbsp;the&nbsp;present&nbsp;study,&nbsp;average&nbsp;dose&nbsp;differences&nbsp;of&nbsp;+1.26%&nbsp;(ranging&nbsp;from&nbsp;+&nbsp;4.99%&nbsp;to&nbsp;􀀀&nbsp;1.73%)&nbsp;and&nbsp;+&nbsp;0.04%&nbsp;(ranging&nbsp;from&nbsp;+&nbsp;3.00%&nbsp;to&nbsp;􀀀&nbsp;3.64%)&nbsp;were&nbsp;observed&nbsp;when&nbsp;the&nbsp;192Ir&nbsp;conversion&nbsp;coefficient&nbsp;was&nbsp;applied&nbsp;and&nbsp;not&nbsp;applied,&nbsp;respectively,&nbsp;in&nbsp;the&nbsp;dose&nbsp;comparisons&nbsp;performed&nbsp;using&nbsp;the&nbsp;specially&nbsp;designed&nbsp;and&nbsp;manufactured&nbsp;applicator.</p><p>Conclusion:&nbsp;This&nbsp;study&nbsp;introduces&nbsp;a&nbsp;clinically&nbsp;applicable&nbsp;MCVC&nbsp;applicator&nbsp;compatible&nbsp;with&nbsp;TLDs&nbsp;for&nbsp;gynecological&nbsp;high-dose-rate&nbsp;(HDR)&nbsp;brachytherapy,&nbsp;enabling&nbsp;accurate&nbsp;pre-treatment&nbsp;and&nbsp;in&nbsp;vivo&nbsp;dose&nbsp;verification.&nbsp;The&nbsp;results&nbsp;support&nbsp;routine&nbsp;use&nbsp;of&nbsp;TLD&nbsp;based&nbsp;patient-specific&nbsp;quality&nbsp;assurance&nbsp;(PSQA)&nbsp;and&nbsp;highlight&nbsp;the&nbsp;need&nbsp;for&nbsp;more&nbsp;precise&nbsp;electronic&nbsp;dosimetry&nbsp;systems.</p>

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