Synthesis and characterization of double molecular imprinted nanoparticles and investigation to adsorption of respiratory drugs
Makaleler > Tam Makale · 2021
Yazarlar: Esra Feyzioglu Demir, Sinan AKGÖL
Polymer-Plastics Technology and Materials, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2021, cilt 61, ss 384-399
DOI: 10.1080/25740881.2021.1991949
Özet
In this study, novel double molecular imprinted nanoparticles (DMIP nanoparticles) with multi-functional monomers were prepared for adsorption of salmeterol xinafoate (SAM) and fluticasone propionate (FLU) drugs. For this purpose, SAM and FLU imprinted poly (2-hydroxyethyl methacrylate-N-methacryloyl-(L)-alanine-N-methacryloyl-(L)-histidine) [p(HEMA-MAAL-MAH)] nanoparticles were synthesized by surfactant-free emulsion polymerization method. After the characterization, adsorption conditions were optimized, and the adsorption kinetics parameters were also calculated. In the selectivity experiments, budesonide (BS) and formoterol fumarate (FF) drugs were used as competitive drugs. These novel development DMIP nanoparticles have the potential for use in many different areas, for purposes such as drug release, separation, and purification.