Preparation of o-bromobenzophenone derivatives from lithium diarylcuprate(I) reagents
Articles > Article ยท 2000
Authors: S Karagoz, DK Astley, Stephen Thomas ASTLEY
APPLIED ORGANOMETALLIC CHEMISTRY, Journal Indexed in SCI Expanded, International, 2000, vol 14, pp 341-344
Summary
The reaction of lithium diarylcuprate(I) reagents with o-bromobenzoyl chloride has been investigated. In general, the reaction proceeds well to give synthetically useful o-bromobenzophenone derivatives as the major product, It is suggested that a minor substituent effect, whereby diarylcuprate reagents containing an ortho or meta substituent react more favourably, may be attributed to small changes in the structure of the organometallic reagent. Copyright (C) 2000 John Wiley & Sons, Ltd.