Evaluation of infection imaging potential of 131I-labeled imidazolium salt
Articles > Article ยท 2018
Authors: Ayca Tuncel, Kasim Ocakoglu, Suleyman Gokhan Colak, Osman Yilmaz, Ismail Ozturk, Fatma YURT
Journal of Radioanalytical and Nuclear Chemistry, Journal Indexed in SCI Expanded, International, WoS, 2018, vol 315, pp 487-492
DOI: 10.1007/s10967-017-5691-2
Summary
Effective antimicrobial compounds are necessary due to increased resistance of antibiotics against microorganisms causing infectious diseases. In this study, imidazolium-TFSI salt [ITFSI: octyl-bis(3-methylimidazolium)-di(bis(trifluoromethane)sulfonimide)] was labeled with I-131 with high efficiency. In vitro uptake experiments of I-131-ITFSI showed high uptake in gram-positive Staphylococcus aureus bacteria. I-131-ITFSI was also evaluated for comparison between bacterial infection and sterile inflammation by in vivo studies. The biodistribution results revealed that I-131-ITFSI might be used as a nuclear imaging agent for detection of bacterial infection.