Evaluation of infection imaging potential of I-131-labeled imidazolium salt
Makaleler > Tam Makale · 2018
Yazarlar: Ayca Tuncel, Kasim Ocakoglu, Suleyman Gokhan Colak, Osman Yilmaz, Ismail Ozturk, Fatma YURT
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2018, cilt 315, ss 487-492
DOI: 10.1007/s10967-017-5691-2
Özet
Effective antimicrobial compounds are necessary due to increased resistance of antibiotics against microorganisms causing infectious diseases. In this study, imidazolium-TFSI salt [ITFSI: octyl-bis(3-methylimidazolium)-di(bis(trifluoromethane)sulfonimide)] was labeled with I-131 with high efficiency. In vitro uptake experiments of I-131-ITFSI showed high uptake in gram-positive Staphylococcus aureus bacteria. I-131-ITFSI was also evaluated for comparison between bacterial infection and sterile inflammation by in vivo studies. The biodistribution results revealed that I-131-ITFSI might be used as a nuclear imaging agent for detection of bacterial infection.