Novel Schiff base-Pt( ii ) complexes: inhibition of Aβ aggregation via histidine interaction
Articles > Article · 2025
Authors: Sevil İRİŞLİ, UMUT DOĞAN, Salih GÜNNAZ, Fatma YURT, ONUR ŞAHİN
New Journal of Chemistry, Journal Indexed in SCI Expanded, International, WoS, 2025, vol 50, pp 1125-1138
DOI: 10.1039/d5nj04180e
Summary
Three novel Schiff base–Pt( ii ) complexes were synthesized and characterized. Complexes I and III showed significant anti-amyloid activity by inhibiting Aβ 1–42 peptide aggregation in vitro , with potential to cross the blood–brain barrier.