Bioevaluation of Tc-99m(CO)(3)-Guanine in vitro and in vivo
Makaleler > Tam Makale · 2011
Yazarlar: Çiğdem İÇHEDEF, Serap TEKSÖZ, Perihan ÜNAK, Kamile SENOCAK, Emin İlker MEDİNE, Turkan Ertay, Recep Bekis
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2011, cilt 292, ss 739-743
DOI: 10.1007/s10967-011-1493-0
Özet
The aim of this study is to examine biological behaviour of radiolabeled guanine with [Tc(CO)(3)](+) core in vitro and in vivo. In vitro biological behavior of Tc-99m(CO)(3)-Gua was evaluated on Lung (A-549), Breast (MCF-7), Colonic (Caco) carcinoma cell lines and normal human bronchial epithelial (NHBE). Tc-99m(CO)(3)-Gua compound showed high uptake on A-549 cell line when compared to NHBE cell line. Biodistribution characteristics of Tc-99m(CO)(3)-Gua was evaluated using New Zeland Rabbits. Scintigraphic results showed that a high level of radioactivity was observed in the lungs and liver shortly after administration of the Tc-99m(CO)(3)-Gua and excretion takes place via both renal and hepatobiliary route. It was concluded that Tc-99m(CO)(3)-Gua could be used as a nucleotide radiopharmaceutical for imaging purposes.