The effect of probiotic supplementation on episiotomy wound healing among primiparous women: a triple-blind randomized clinical trial
Makaleler > Tam Makale · 2023
Yazarlar: Derakhshan Abdollahpour, Aziz Homayouni-Rad, Roghaiyeh Nourizadeh, Sevıl HAKIMI, Esmat Mehrabi
BMC COMPLEMENTARY MEDICINE AND THERAPIES, SCI İndekslerine Giren Dergi, Uluslararası, Wos, 2023, cilt 23, ss 3-12
DOI: 10.1186/s12906-023-03980-3
Özet
BackgroundProbiotics increase the defense power of immune system and accelerate the wound healing process by anti-inflammatory mechanisms at the wound site. The present study aimed at evaluating the effect of Lactobacillus casei oral supplementation on episiotomy wound healing among primiparous women.MethodsThis triple-blind randomized clinical trial was performed on 74 primiparous women delivered in Alzahra Hospital, Tabriz, Iran. Participants with mediolateral episiotomy (incision length equal to and less than 5 cm) were randomly assigned to the probiotic and placebo groups. The probiotic group received Lactobacillus casei 431 with 1.5 * 10(9) colony-forming unit /capsule once a day from the day after birth to 14 days. Wound healing as a primary outcome was measured by Redness, Edema, Ecchymosis, Discharge, Approximation and pain as a secondary outcome by the Visual Analogue Scale before discharge, 5 +/- 1 and 15 +/- 1 days after birth. The data were analyzed using independent t-test and repeated measures one way analysis of variance.ResultsThe mean (standard deviation: SD) score of wound healing in the probiotic group altered from 4.91(1.86) before discharge to 1.55 (0.99) during 5 +/- 1 days after birth and reached to 0.95 (0.27) during 15 +/- 1 days after birth. Further, the mean (SD) score of wound healing in the placebo group altered from 4.62 (1.99) before discharge to 2.80 (1.20) during 5 +/- 1 days after birth and reached to 1.45(0.71) during 15 +/- 1 days after birth (adjusted mean difference: -0.50, confidence interval 95%: -0.96 to -0.05, P = 0.03).ConclusionLactobacillus casei oral supplementation is effective in healing episiotomy wounds. It is suggested to evaluate the effect of topical use of Lactobacillus casei on episiotomy repair and pain in further studies.