Alginate as an immobilization material for MAb production via encapsulated hybridoma cells
Articles > Article · 2010
Authors: S. Mert Selimoglu, Murat ELİBOL
Critical Reviews in Biotechnology, Journal Indexed in SCI Expanded, International, WoS, 2010, vol 30, pp 145-159
DOI: 10.3109/07388550903451652
Summary
Alginate has been widely used in various applications since its first extraction. What makes this biopolymer useful is its high biocompatibility and humid gelation conditions. Both of these features bring it into prominence as an ideal immobilization material. However, there are some complicated aspects of cell immobilization using alginate biopolymers. This review discusses and clarifies these crucial points, using as an example the bioprocessing of highly fragile cells (hybridoma cells). The review focuses on the cultivation and production of alginate encapsulated cells.