Identification of Candida species and investigating antifungal susceptibility in Turkey
Makaleler > Tam Makale · 2014
Yazarlar: E. Aydin, A. Karakas, U. Savasci, Y.K. Akpak, S.O. Caymaz, S. Aydin, Dilek Yeşim METİN, O. Ozgenc, M. Avci, H.C. Gul, O. Coskun, S.A. Coskuner
International Journal of Infectious Diseases, Uluslararası, Wos, 2014, cilt 21, ss 289-289
DOI: 10.1016/j.ijid.2014.03.1020
Özet
Background: The purpose of this study is develop a typology of candida species produced from patient samples, and determine their in-vitro antifungal susceptibility. Methods & Materials: In this study, Candida species isolated from patients who applied to our laboratory between 2009-2010 were included in order to identify the types of Candida and to carry out their antifungal sensitivity. The Candida species were were typed using germ tube test, corn meal Tween-80 and BBL CHROMagar medium, and API ID32C yeast identification system. Antifungal susceptibility of Candida species for amphotericin B, fluconazole, itraconazole, and voriconazole were conducted through microdilution system. Results: Of the 97 Candida species, 58.76% were identified as Candida albicans, other identified types were as follows: C. parapsilosis (13.4%), C. glabrata (11.3%), C. tropicalis (5.15%) respectively. As for the antifungal sensitivity tests, results revealed 1.03% resistance to fluconazole and 4.12% to itraconazole, whereas no resistance was found to amphotericin B and voriconazole. Conclusion: Target population for Candida has gradually been expanding. Therefore, it may be suggested that determining the type of pathogen and running its susceptibility tests are significant factors that will enhance the success of the treatment before empirical treatment against Candida infections is initiated.