Silver( i ) NHC complexes with antimicrobial and anticancer potential: synthesis, characterization, and DFT-derived molecular insights
Makaleler > Tam Makale · 2026
Yazarlar: Öznur Doğan Ulu, Nour-Elhouda Belazghem, Sümeyya Serin, Hüseyin Karcı, Muhammed Dündar, Khaled Sekkoum, İlknur Özdemir, İlkay Yıldırım, Namık Özdemir, Bekir Çetinkaya, İsmail Özdemir
RSC Advances, Uluslararası, Wos, 2026, cilt 16, ss 40332-40351
DOI: 10.1039/d6ra03398a
Özet
. In addition, the anticancer properties of the compounds were assessed using HCT116 (human colorectal carcinoma), A549 (human lung cancer), and BEAS-2B (human normal lung epithelial) cell lines to determine their cytotoxic and selective antiproliferative effects. Overall, among the synthesized Ag-NHC complexes, 3a and 3e appear to be the most promising candidates for further development. Furthermore, the stability of the complexes in the biological media and their protein binding properties were investigated and the results revealed that the complexes displayed satisfactory stability and albumin-binding properties. Finally, DFT calculations were employed to optimize the molecular geometries and to investigate the electronic, thermodynamic, and vibrational properties of the complexes. FMO, NBO, and MEP analyses provide insight into the distribution of electron density and the nature of metal-ligand interactions.