Hydrophobic uptake and voltammetry of ergot alkaloids at lipid‐coated electrodes
Makaleler > Tam Makale · 1990
Yazarlar: Joseph Wang, Mehmet Ozsoz
Electroanalysis, Uluslararası, 1990, cilt 2, ss 595-599
Özet
Abstract The ergot alkaloids, ergotamine tartarate, ergonovine maleate, and ergocristine, are shown to be effectively partitioned into a lipid layer on a glassy carbon electrode. Such hydrophobic accumulation greatly enhances the sensitivity and selectivity of the subsequent voltammetric scan. A high degree of selectivity is achieved as polar electroactive species (present at large excess) are excluded by the hydrophobic layer. Detection limits of 1 × 10−8 M for ergotamie tartarate, 3 × 10−7 M for ergocristine, and 1 × 10−6 M for ergonovine maleate are attained (3 minute accumulation). Numerous variables affecting the response are explored. Differences in the hydrophobicity of ergot alkaloids account for changes in hydrophobic uptake and, hence, sensitivity. Applicability to selective measurements in untreated urine samples is illustrated.