How narrow is narrow QRS in premature ventricular contractions? A novel variant of SCN5A-associated MEPPC
Articles > Article · 2025
Authors: Oğuzhan Ekrem Turan, Sercan Karaoğlan, Ayça AYKUT, Asude DURMAZ, Reşit Yiğit Yiıancıoğlu, Emin Evren Özcan
HeartRhythm Case Reports, International, Scopus, 2025, vol 11, pp 689-692
DOI: 10.1016/j.hrcr.2025.05.004
Summary
Gain-of-function mutations in the SCN5A gene may cause Multifocal Ectopic Purkinje-related premature Contractions (MEPPC) linked to Purkinje system hyperpolarization and dilated cardiomyopathy. [1] This case highlights the importance of genetic testing in diagnosing arrhythmias and tailoring antiarrhythmic therapy.