Impact of the empirical therapy timing on the clinical progress of septic shock patients
Makaleler > Tam Makale · 2024
Yazarlar: Deniz Akyol, İlkin Çankayalı, Murat ERSEL, Kubilay DEMİRAĞ, Mehmet Uyar, Özge Can, Özge Can, Enver ÖZÇETE, Funda KARBEK AKARCA, Tahir YAĞDI, Çağatay ENGİN, Erkin Özgiray, Taşkın Yurtseven, Burcu Yağmur, Sanem NALBANTGİL, Pervin Ekren, Devrim Bozkurt, Hadiye Şirin, Feriha Çilli, Ebru Demirel Sezer, Meltem TAŞBAKAN, Tansu YAMAZHAN, Hüsnü PULLUKÇU, Hilal Sipahi, Bilgin ARDA, Sercan Ulusoy, Sercan Ulusoy, Oğuz Reşat Sipahi
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2024, cilt 108, ss 116149-116149
DOI: 10.1016/j.diagmicrobio.2023.116149
Özet
Aim: To evaluate the effect of timing of antimicrobial therapy on clinical progress of patients with septic shock. Materials and Method: We included 204 adult patients diagnosed with septic shock according to Sepsis-3 criteria between March 2016 and April 2021. One-month survival was evaluated using univariate and logistic regression analysis. Results: Antibiotic treatment was initiated within 1 h of the vasopressors in 26.4 % of patients. One-month mortality did not differ significantly between patients with and without empirical therapy coverage on etiological agents. Univariate factors that significantly affected one-month survival were starting antibiotics at the first hour, the unit where the case was diagnosed with septic shock, SOFA scores, qSOFA scores, and lactate level. In multivariate analysis, diagnosis of septic shock in the Emergency Service, SOFA score ≥11, qSOFA score of three and lactate level ≥4 were significantly associated with one-month mortality. Conclusion: Training programs should be designed to increase the awareness of septic shock diagnosis and treatment in the Emergency Service and other hospital units. Additionally, electronic patient files should have warning systems for earlier diagnosis and consultation.