Effect of inhaled steroid therapy on treatment response in hosptalized pneumonia patients: Results from Turkish Thoracic Society database
Bildiriler > Özet Bildiri
Yazarlar: Ayse Baha, Nurdan Kokturk, Sakine Bahcecioglu, Canan Gunduz, Sezai Tasbakan, Abdullah SAYINER, Aysin Coskun, Feride Durmaz, Aykut Cilli, Burcu Celenk, Oguz Kilinc, Seda Salman, Armagan Hazar, Fatma Tokgoz
10.1 Respiratory Infections, , , Uluslararası, Özet Bildiri, ss PA2567-PA2567
DOI: 10.1183/13993003.congress-2015.pa2567
Özet
Aim: In the literature, there is no study that focuses on frequency of ICS use and the differences between ICS users and non-users in patients with pneumonia.Our aim is to search for differences regarding clinical characteristics,laboratory parameters,duration of hospitalization and response to treatment between ICS users and pneumonia patients. Methods: 1069 patients were included in the study.Patients(n:922) were divided into two groups as ICS users and non-users.Differential characteristics of pneumonia in ICS users were evaluated using regression analysis. Results: 227out of 922patients were using ICS.ICS use was associated with older age(p=0.0001),higher rates of smoking(p=0.02),higher values of PCO2(p=0.0001)and patchy infiltrations(p=0.011) on thorax computerized tomography(CT).On the other hand,it was associated with lower values of PO2(p=0.016),PO2/FiO2(p=0.017) and lower rates of mortality(p=0.006),less common fever(p=0.013),gastrointestinal symptoms(p=0.22),myalgia(p=0.015),pleural effusion (p=0.002) and consolidations on chest x-ray(p=0.01).Mean duration of hospitalization for ICS users was 14.35±5.57 days and 15,8±8,85 days for non-users(p=0.5).According to regression analyses,ICS was associated with lower prevalences of consolidations on chest x-ray(p=0.011) and pleural effusion (p=0.014) and higher prevalences of patchy infiltrations on thorax CT(p=0.003) and accompanying COPD(p=0,0001). Conclusion: ICS use is associated with better treatment response and lower mortality rates in hospitalized pneumonia patients in contrary to what is expected. New larger-scaled studies are warrented regarding our topic.