A second Middle Eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9
Makaleler > Tam Makale · 1998
Yazarlar: SM LEAL, Fazıl APAYDIN, C BARNWELL, M IBER, T KANDOGAN, M PFISTER, U BRAENDLE, O CURA, M SCHWALB, HP ZENNER, E VITALE
European Journal of Human Genetics, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 1998, cilt 6, ss 341-344
Özet
A second kindred has been identified which supports the previously reported location of DFNB9. Linkage has been established to markers closely linked to DFNB9 which is located on 2p22-p23. The hearing impaired individuals in this highly consanguineous kindred from Eastern Turkey have prelingual profound hearing loss which affects all frequencies. A genetic map of the 2p22-p23 region where DFNB9 resides was generated using marker genotypes available from the CEPH database. All markers were placed on this genetic map using a likelihood ratio criterion of 1000:1. This map suggests that the region for DFNB9 is less than 1.08 cM, 95% confidence interval (0-2.59 cM).