Effect of transjugular intrahepatic portosystemic shunt on thrombocytopenia associated with cirrhosis
Makaleler > Tam Makale · 2000
Yazarlar: Abdullah Zeki KARASU, A Gurakar, B Kerwin, S Hulagu, A Jazzar, R McFadden, B Nour, A Sebastian, F Cassidy, K Stokes, H Wright
DIGESTIVE DISEASES AND SCIENCES, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2000, cilt 45, ss 1971-1976
Özet
Thrombocytopenia is a frequent complication of cirrhosis. Its pathogenesis is not well known, but it has been suggested that splenic congestion induced by portal hypertension may be a major contributory factor. However, the available data regarding the effect of portal decompression either by surgical shunts or transjugular intrahepatic portosystemic shunt (TIPS) on peripheral platelet count in cirrhotics is conflicting. We studied the effects of TIPS on platelet count and mean platelet volume, following a successful TIPS placement. The platelet count had a tendency to decrease but was not statistically significant (120,100 +/- 72,100/mm(3) before TIPS vs 99,800 +/- 51,400/mm(3) after TIPS). The mean platelet volume remained essentially unchanged (9.8 +/- 1.5 fL before TIPS and 9.9 +/- 1.5 fL after TIPS). These results confirm that TIPS has an unpredictable effect on platelet count in cirrhotic patients with thrombocytopenia. The lack of a consistent increase in the peripheral mean platelet volume following TIPS placement suggests that TIPS is unable to significantly enhance the release of platelets sequestered in the splenic compartment in portal hypertension.