Prevalence and characteristics of insomnia phenotype in mild sleep apnoea patients from the ESADA study population
Bildiriler > Özet Bildiri · 2017
Yazarlar: Izolde BOULOUKAKI, Paschalis Steiropoulos, Maria Bonsignore, Jan HEDNER, Athanasia PATAKA, Ludger GROTE, Oreste MARRONE, Johan VERBRAECKEN, Özen KAÇMAZ BAŞOĞLU, Carlo Lombardi, Sophia SCHIZA
Sleep and Control of Breathing, İtalya, Uluslararası, Sözlü Sunum, Özet Bildiri, 2017-2017, Wos, cilt 50, ss PA327-PA327
DOI: 10.1183/1393003.congress-2017.pa327
Özet
Background: There are limited data concerning symptoms and comorbidities in mild obstructive sleep apnoea (OSA) patients. Aims and Objectives: To explore clinical phenotypes of mild OSA patients and their possible association with comorbidities. Methods: A prospective follow-up cohort of 3947 adult patients with mild OSA [apnoea-hypopnoea index (AHI) of 5-15/h] from the ESADA study was divided into four clinical phenotypes based on the presence of excessive daytime sleepiness (EDS) and/or symptoms and signs of insomnia): 1)EDS (daytime+/nighttime-), 2) EDS/insomnia (daytime+/nighttime+), 3) non-EDS/non insomnia (daytime-/nighttime-), 4) and insomnia (daytime-/nighttime+) phenotype. Results: The distribution of the four phenotypes were 18.9, 26.5, 19.1 and 35.5%, respectively. Sleep apnea severity expressed as AHI or the oxygen desaturation index (ODI) did not differ significantly between groups. The insomnia phenotype patients were older (p<0.001), more frequently female (p<0.05) and current smokers. Additionally, cardiovascular comorbidity was more common in the insomnia phenotype compared with the EDS and EDS-insomnia phenotypes (56.8 vs 48.9 and 41.5%, p=0.022 and p=0.01 respectively). Metabolic, pulmonary and psychiatric comorbidities were more prevalent in the insomnia phenotype (p<0.05). Conclusion: Our findings suggest that a phenotype characterized by symptoms and/or signs of insomnia, accounts for a higher prevalence of cardiometabolic disease among patients with mild OSA.