Epigenetic Regulation of Breast and Prostate Cancer
Makaleler > Tam Makale · 2019
Yazarlar: Ceren Gonen Korkmaz
Journal of Clinical and Medical Research, Uluslararası, 2019
DOI: 10.37191/mapsci-2582-4333-2(2)-025
Özet
Aim: Epigenetic investigates gene expression modifications not due to DNA sequence alterations. Gene expression modifications appear with packing of DNA with variety of chromatine structures. Materials and Methods: The most studied forms of epigenetic phenomenon are DNA methylation and histone modifications. These pathways are connected with each other and reversible. DNMT family members which take place at epigenetic mechanism DNMT1, 3a also shown at breast cancer MCF-7 and prostate cancer brain-metastasis- DU145 with RT- PCR and western methods. Results: Histone modification which close the gene expression is histone deacetylation had been reversed by Trichostatin A(TSA). It is reported that inhibition of methylation and deacetylation in a serial way result with succesful gene activation, performed with5-aza-2’- deoksitidin and TSA incubation at the project. Conclusion: In the recent years, epigenetic base had been shown for many diseases that research and development for epigenetic disorders won successful treatment cases. Preclinic and clinic levels of candidate drugs are on the way.