Giant cell hepatitis and autoimmune hemolytic anemia after chickenpox
Articles > Article · 2010
Authors: Maşallah Baran, Funda ÇETİN, Ömer BERK, Demir GÖKÇE, Kaan KAVAKLI, Funda YILMAZ, Sait ŞEN, Raşit Vural YAĞCI
Turkish Journal of Gastroenterology, International, 2010, vol 21, pp 448-451
Summary
Autoimmune hemolytic anemia with giant cell hepatitis is a distinct entity in children. It is usually fatal with progressive liver disease. Immunosuppressive treatment with conventional drugs offers some response; however, it is usually only temporary. Alternative therapeutic options with monoclonals have been reported with promising remission of the disease. We report a case with autoimmune hemolytic anemia+giant cell hepatitis after varicella infection. She was resistant to standard immunosuppressive combinations, and rescue therapy with rituximab was used. Remission was not achieved with the drug and the child died with septic complication.