Protective effect of oxytocin on ovarian ischemia-reperfusion injury in rats
Articles > Article · 2014
Authors: Ali AKDEMİR, Oytun ERBAŞ, Funda GODE, Ahmet Mete ERGENOĞLU, Ahmet Özgür YENİEL, Fatih OLTULU, Altuğ YAVAŞOĞLU, Dilek TAŞKIRAN
PEPTIDES, Journal Indexed in SCI Expanded, International, 2014, vol 55, pp 126-130
DOI: 10.1016/j.peptides.2014.02.015
Summary
Oxytocin (OT), a neurohypophysial nonapeptide, plays dual role as a neurotransmitter/neuromodulator and a hormone. It has also well known protective properties against ischemia/reperfusion organ damage. This study investigated the effect of OT on experimentally induced ovarian torsion/de-torsion ischemia/reperfusion (I/R) injury in rats. Sprague-Dawley rats were assigned to five treatment groups (n = 7/group): Group 1, sham-operated; Group 2, torsion; Group 3, 80 IU/kg of OT administration 30 min prior to torsion; Group 4, torsion/de-torsion; and Group 5, torsion followed by 80 IU/kg of OT administration 30 min prior to de-torsion. OT administration significantly decreased the tissue malondialdehyde (MDA) levels in both the torsion and OT group (Group 3), and torsion/de-torsion OT group (Group 5) in comparison with the torsion-only group (Group 2) and torsion/de-torsion group (Group 4). Histopathological finding scores including follicular degeneration, edema, hemorrhage, vascular congestion, and infiltration by inflammatory cells were found to be significantly decreased in the torsion and OT group (Group 3), and torsion/de-torsion OT group (Group 5) when compared with the torsion-only group (Group 2) and torsion/de-torsion group (Group 4). In conclusion, these results, verified with histopathologic evaluation and biochemical assays, suggest a probable protective role for OT in ischemia and I/R injury in rat ovaries. (C) 2014 Elsevier Inc. All rights reserved.