Encapsulated Chlorhexidine Digluconate Usage on the Diabetic Footwear Lining Leathers
Conference paper > Full Text
Authors: Hüseyin Ata KARAVANA, Seda Rençber, Sinem Yaprak KARAVANA, Fatih Yalçin
The International Conference on Advanced Materials and Systems, , , International, Full Text, Scopus, pp 257-262
DOI: 10.24264/icams-2016.ii.11
Summary
It is important for a therapeutic shoe to have a wearable quality and its comfortable use is also prominent in terms of providing an increase in user's quality of life.In long-term treatment of diseases, medical products which are to be manufactured with medical leather materials might be a prominent alternative via local effect application as an adjuvant to the treatment.It is aimed in this study to produce microparticles (MPs) which contain the active agent chlorhexidine digluconate and application of these MPs on lining leather for manufacturing diabetic shoes while providing them a functional quality.Within the scope of the project, MPs loaded with drugs were obtained via spraying chlorhexidine digluconate (CHD) active agent and through spraying with ethyl cellulose polymer and ustulation.In vitro characterisation studies were performed on the acquired MPs.Additionally, active agent quantitation and in vitro drug delivery studies were also performed.Following the studies, the determined optimum MP formulations were applied on the leather, then existence and efficiency of MPs within the leather was shown in the subsequent studies.