High-resolution CT phenotypes in pulmonary sarcoidosis: a multinational Delphi consensus study
Makaleler > Tam Makale · 2024
Yazarlar: Sujal R. Desai, Nishanth Sivarasan, Kerri A. Johannson, Peter M. George, Daniel A. Culver, Anand Devaraj, David A. Lynch, David Milne, Elisabetta Renzoni, Hilario Nunes, Nicola Sverzellati, Paolo Spagnolo, Robert P. Baughman, Ruchi Yadav, Sara Piciucchi, Simon L.F. Walsh, Vasileios Kouranos, Athol U. Wells, Adam Anderson, Adam Morgenthau, Adrian Gaser, Alexander Vizel, Alexander Vizel, Alexandra Speranskaya, Alicia Gerke, Altinisik Goksel, Alvaro Undurraga, Amita Sharma, Amita Sharma, Amita Sharma, Andrea Oh, Andrea Oh, Ann Leung, Ann Leung, Anna Rita Larici, Antje Prasse, Antonietta Mazzei, Antonietta Mazzei, Antonio Morais, Ashu Bhalla, Ashu Bhalla, Belen Del Rio, Belen Del Rio, Belen Del Rio, Bhavin Jankharia, Brett Elicker, Carlos Pereira, Carlos Pereira, Catherine Biegelman-Aubry, Charles White, Claudia Ravaglia, Connie Hsia, Connie Hsia, Connie Hsia, Cornelia Schaefer-Prokop, David Launay, Deepak Talwar, Diego Castillo, Divya Patel, Dominique Israel-Biet, Dominique Valeyre, Edward James Britt, Edward James Britt, Elena Bargagli, Elisabeth Bendstrup, Elliott Crouser, Esther Nossent, Eugeny Shmelev, Eugeny Shmelev, Eugeny Shmelev, Eva Carmona Porquera, Eva Carmona Porquera, Francesco Bonella, Francesco Bonella, Fleur Cohen-Aubart, Florence Jeny, Giovanni Ferrara, Gong Yong Jin, Gong Yong Jin, Hasti Robbie, Helmut Prosch, Hiromitsu Sumikawa, Ho Ling-Pei, Ho Yun Lee, Irina Strambu, Ivette Buendia-Roldan, Jan Grutters, Jay Ryu, Jay Ryu, Jeff Swigris, Jelle Miedema, Jin Mo Goo, Jin Mo Goo, Jin Mo Goo, Joseph Barnett, Johny Verschakelen, Jonathan Goldin, Joon Beom Seo, Juan Enghelmayer, Juan Mana, Nesrin MOĞULKOÇ BISHOP
LANCET RESPIRATORY MEDICINE, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2024, cilt 12, ss 409-418
DOI: 10.1016/S2213-2600(23)00267-9
Özet
One view of sarcoidosis is that the term covers many different diseases. However, no classification framework exists for the future exploration of pathogenetic pathways, genetic or trigger predilections, patterns of lung function impairment, or treatment separations, or for the development of diagnostic algorithms or relevant outcome measures. We aimed to establish agreement on high-resolution CT (HRCT) phenotypic separations in sarcoidosis to anchor future CT research through a multinational two-round Delphi consensus process. Delphi participants included members of the Fleischner Society and the World Association of Sarcoidosis and other Granulomatous Disorders, as well as members' nominees. 146 individuals (98 chest physicians, 48 thoracic radiologists) from 28 countries took part, 144 of whom completed both Delphi rounds. After rating of 35 Delphi statements on a five-point Likert scale, consensus was achieved for 22 (63%) statements. There was 97% agreement on the existence of distinct HRCT phenotypes, with seven HRCT phenotypes that were categorised by participants as non-fibrotic or likely to be fibrotic. The international consensus reached in this Delphi exercise justifies the formulation of a CT classification as a basis for the possible definition of separate diseases. Further refinement of phenotypes with rapidly achievable CT studies is now needed to underpin the development of a formal classification of sarcoidosis.