Spinonin, a Novel Glycoside from Ononis spinosa subsp. leiosperma
Makaleler > Tam Makale · 1997
Yazarlar: Süheyla Kırmızıgül, Nezhun Gören, Shu-Wei Yang, Geoffrey A. Cordell, Candan Bozok-Johansson
Journal of Natural Products, Uluslararası, Wos, 1997, cilt 60, ss 378-381
DOI: 10.1021/np9605652
Özet
The roots of Ononis spinosa subsp. leiosperma (Leguminosae) afforded a new glycoside, spinonin (1), possessing a novel skeleton, in addition to the known isoflavonoid glycoside, ononin [7beta-(glucosyloxy)formononetin] (2) and the known pterocarpan, 7-demethoxy-7-D-(glucosyloxy)homopterocarpin (3). The structure of the new isolate was elucidated by spectral methods including 1H and 13C NMR, COSY, APT, HETCOR, HMBC, NOESY, CD, FABMS, HRMS, EIMS, CIMS, and some chemical reactions. Spinonin was inactive against a number of human cancer cell lines and HIV-1 reverse transcriptase. The compounds 1 and 3 showed weak activity against Pseudomonas aeruginosa, whereas 2 was active against beta-hemolytic Streptococcus.