Evaluation of Organic Load Related Efficacy Changes in Antiseptic Solutions Used in Hospitals
Makaleler > Tam Makale · 2022
Yazarlar: Aslı ŞAHİNER DANIŞKAN, ECE HALAT, EVREN ALĞIN YAPAR, BİLGE AHSEN KARA
Turkish Journal of Medical Sciences, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2022, cilt 52, ss 825-833
Özet
the leading microorganisms associated with hospitalacquired infections [5,7,8].Candida albicans, the most important fungus in terms of nosocomial infections, causes septicaemia, urinary tract infections, or surgical site infections.Antiseptic solutions containing hydrogen peroxide, chlorhexidine, triclosan, ethyl alcohol, and povidone-iodine active substances are formulated as ready-to-use or concentrated solutions for hand hygiene and wound antisepsis in the hospitals.Most antiseptics do not have a specific form of action against microorganisms as much as antibiotics, but their microbial activities show significant differences depending on many factors such as the presence of organic matter, microbial load, and synergistic effects between active substances, time, and temperature.The effects of some active substances may be reduced due to various effects, especially in the presence of organic substances, and cannot show the expected microbial reduction [2,9,10].In addition to being used in the hospital environment, antiseptic solutions are widely used all over the world due to the Covid 19 pandemic.In this direction, it has become more important to investigate the factors affecting the effectiveness of antiseptic solutions.The failure to achieve the desired success in the use of Background/aim: In this study, it was aimed to evaluate the change in antimicrobial efficacy related to the presence of the organic load of four different antiseptic solutions that are frequently used in hospitals.Materials and methods: Solutions of hydrogen peroxide, povidone-iodine, chlorhexidine digluconate, and ethyl alcohol were prepared, tested in terms of antimicrobial efficacy changes in the presence of organic substances, and evaluated according to EN 13727 and EN 13624 standards.Results: Among the investigated solutions ethanol 70% solution showed the best results by providing a 5-log reduction on all test organisms without affecting by the type and concentration of organic substances.Solutions of hydrogen peroxide 3%, povidone-iodine 7.5%, and chlorhexidine digluconate 0.2% performed lower antimicrobial efficacy depending on the concentration of organic load.Conclusion: It is concluded that the antimicrobial efficacy of antiseptic solutions is significantly affected by the organic substances and thus the proper use of antiseptics has become important to achieve successful disinfection and prevention of antibacterial resistance.