Magnetic nanoparticle-conjugated and radioiodinated-DESG: in vitro and in vivo efficiency investigation
Makaleler > Tam Makale · 2014
Yazarlar: Tayfun YILMAZ, Perihan ÜNAK, Fazilet Zümrüt BİBER MÜFTÜLER, Emin İlker MEDİNE, Çiğdem İÇHEDEF, Ayfer YURT KILÇAR
Journal of Radioanalytical and Nuclear Chemistry, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2014, cilt 303, ss 63-69
DOI: 10.1007/s10967-014-3329-1
Özet
The purpose of this work is to combine magnetite nanoparticles with radioiodinated diethylstilbestrol-glucuronide (DESG) to get a prostate cancer agent. Magnetically targeted drug delivery by particulate carriers is an efficient method of delivering drugs to localized and targeted disease sites, such as tumors. Estrogen glucuronide derivative; DESG was synthesized which is specific for beta glucuronidase enzyme consisting tumor cells and conjugated with iron oxide nanoparticles (NP) and radioiodinated with I-125/131 to evaluate in vitro/in vivo radiopharmaceutical potential of NP conjugated DESG (NP-DESG) and magnetic field applied NP-DESG (MNP-DESG). According to cell culture studies, incorporation ratios of MNP-DESG were higher in MCF7 cells than A549 and Caco2 cells. Biodistribution experiments were verified that the range of the breast/blood and breast/muscle ratios was approximately between 1.82 and 10.10 in 240 min for ER unsaturated studies. The results are promising for targeted therapy of both estrogen receptor and enzyme beta-glucuronidase rich cancers.