Can hyperbaric oxygenation decrease doxorubicin hepatotoxicity and improve regeneration in the injured liver?
Articles > Article · 2009
Authors: Özgür FIRAT, Ozgur KIRDOK, Özer MAKAY, Cemil ÇALIŞKAN, Funda YILMAZ BARBET, Savas ILGEZDI, Bulent Karabulut, Ahmet Coker, Murat ZEYTÜNLÜ
Journal of Hepato-Biliary-Pancreatic Surgery, Journal Indexed in SCI Expanded, International, WoS, 2009, vol 16, pp 346-352
DOI: 10.1007/s00534-009-0059-9
Summary
Portal vein embolization is used in the treatment of hepatocellular cancer, with the purpose of enhancing resectability. However, regeneration is restricted due to hepatocellular injury following chemotherapeutics (e.g. doxorubicin). The aim of this study was to investigate whether hyperbaric oxygenation (HBO) can alleviate the hepatotoxicity of chemotherapy and improve regeneration in the injured liver.