Electrochemical Monitoring of Nucleic Acid Hybridization by Single‐Use Graphene Oxide‐Based Sensor
Articles > Article · 2010
Authors: Mihrican Muti, Surbhi SHARMA, Kadriye Arzum ERDEM GÜRSAN, Pagona Papakonstantinou
Electroanalysis, Journal Indexed in SCI Expanded, International, WoS, 2010, vol 23, pp 272-279
Summary
Abstract In this paper, the application of a Graphene oxide (GRPox) integrated on single‐use pencil graphite electrode (PGE) for the enhanced monitoring of nucleic acids and for the sensitive and selective detection of the label free DNA hybridization related to Hepatitis B virus (HBV) sequences is described. Electrochemical behaviors of GRPox modified PGEs were firstly investigated using electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). The sequence selective DNA hybridization was determined voltammetrically in the case of hybridization between amino linked probe and its complementary (target), or, noncomplementary (NC), or target/mismatch (MM) mixtures (1 : 1).