Differential expression of full-length and NH2 terminally truncated FAM134B isoforms in normal physiology and cancer
Articles > Article · 2020
Authors: Umur Keleş, Evin İşcan, Huriye Erbak Yılmaz, Gokhan Karakülah, Aslı SUNER KARAKÜLAH, Erhan Bal, Nilgün Taşdemir, Ayşe Derya Cavga, Umut Ekin, Zeynep Mutlu, Sıla Kahyaoğlu, Muhittin Abdülkadir Serdar, Neşe Atabey, Mehmet Öztürk
American Journal of Physiology-Gastrointestinal and Liver Physiology, Journal Indexed in SCI Expanded, International, WoS, 2020, vol 319, pp G733-G747
Summary
We reported tissues expressing FAM134B-2 such as the kidney, muscle, heart, and pancreas, some of which exhibit stimulated expression upon nutrient starvation. We also demonstrated the effect of Fam134b deletion during ad libitum and starvation conditions. Resistance to weight loss and hypocalcemia, accompanied by an increase in serum albumin and α-amylase levels, indicate critical roles of Fam134b in physiology. Furthermore, the differential expression of FAM134B isoforms was shown to be significantly dysregulated in human cancers.