Leukemia Cutis and Second Primary Malignant Melanoma: An Extraordinary Case Report
Makaleler > Tam Makale · 2014
Yazarlar: Banu YAMAN, Nazan ÖZSAN, Nisar Karadeniz, Tuğrul Dereli, Taner AKALIN, Gülşen Kandiloğlu
American journal of cancer case reports, Uluslararası, 2014, cilt 2, ss 79-85
Özet
Introduction: Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common leukemia of adult. Patients with CLL/SLL are at higher risk for secondary malignancies such as skin, breast or lung tumours. Cutaneous infiltrates of CLL/SLL have been reported in association with squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and actinic keratosis. Case Presentation: We present a patient with a previous history of CLL/SLL who developed a primary skin melanoma in the same area of leukemic infiltration, with the histological and immunohistochemical features. An 80-year-old man presented with an 3 cm nonpigmented, erythematous and ulcerated plaque on the abdomen. Microscopically, a primary melanoma with an ulcer and skin infiltration of CLL/SLL at the ulcer base was seen. Conclusion: Secondary cutaneous neoplasms can develop in patients with CLL/SLL and CLL/SLL infiltration can be associated with melanoma as in our case. The finding of a dense infiltrate of lymphocytes in cutaneous tumors should raise possibility of CLL/SLL and lead to a detailed examination.