Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma
Makaleler > Tam Makale · 2017
Yazarlar: Cliff I. Oduor, Yasin KAYMAZ, Kiprotich Chelimo, Juliana A. Otieno, John Michael Ong'echa, Ann M. Moormann, Jeffrey A. Bailey
BMC CANCER, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2017, cilt 17
DOI: 10.1186/s12885-017-3711-9
Özet
Background: Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex amalgam of genetic and epigenetic changes causing dysregulation of both coding and non-coding transcripts. Emerging evidence suggest that abnormal modulation of mRNA transcription via miRNAs might be a significant factor in lymphomagenesis. However, the alterations in these miRNAs and their correlations to their putative mRNA targets have not been extensively studied relative to normal germinal center (GC) B cells.