GC/MS analysis of alkaloidal axtracts from Hypecoum procumbens L. subsp. atropunctatum Å. E. Dahl
Bildiriler > Tam Metin Bildiri
Yazarlar: B Bozkurt, E Kaynar, H Gurgen, N Unver Somer
Planta Medica, , , Uluslararası, Tam Metin Bildiri, Wos, cilt 92
Özet
Plants belonging to the genus Hypecoum Tourn. ex L. (Papaveraceae) are widely distributed from the Mediterranean region to Central Asia and Northern China [ 1 ]. Among the Hypecoum species found in Turkey, Hypecoum procumbens L. is represented by two subspecies [ 2 ]. Phytochemical characterization of Hypecoum species reveals that the main active constituents are isoquinoline alkaloids with various chemical classes and biological activities which could be considered as significant chemotaxonomic markers. Among these protopine is the main alkaloid isolated from the species of this genus and it has been shown to possess important biological properties, including antimicrobial, anticancer and anti-inflammatory activities [ 1 ] [ 3 ]. In the present study, the alkaloidal profiles of the extracts of plant specimens collected from four different localities in Western Turkey, were analyzed by GC/MS by using a previously described method [ 4 ]. As a result, isoquinoline alkaloids belonging to different chemical groups were detected in variable amounts. Protopine, a representative alkaloid of protopines, was the predominant alkaloid in all of the extracts detected within the range of 69.39-96.2%. Leptopinine (secoberbine type) was also found in significant amounts (3.72-23.03%) in the extracts. Dihydrosanguinarine (benzophenanthridine type) and a simple isoquinoline alkaloid oxyhydrastinine were detected up to 6.51% and 1.07%, respectively. As evident from the literature [ 1 ] [ 3 ], the phytochemical investigation of Hypecoum species is important as the structural types of the identified isoquinoline alkaloids can be used to determine the relationships between members of this genus and other genera in the Papaveraceae family. Funding This study is partially supported by Ege University Research Project (13/ECZ/001). Publication History Article published online: 05 March 2026 © 2026. Thieme. All rights reserved. Georg Thieme Verlag KG Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany