Denizel biyoaktif bileşikler.
Makaleler > Tam Makale · 2013
Yazarlar: Ferhat Can Özkaya, Cem Erdoğan, Muhammet Altunok
Ege Journal of Fisheries and Aquatic Sciences, Uluslararası, 2013, cilt 30, ss 85-92
DOI: 10.12714/egejfas.2013.30.2.08
Özet
Natural products and their derivate compounds have been underlined of new drugs along centuries.The compounds which are named secondary metabolites are produced by organisms against to predators in nature.Initially various terrestrial plants were investigated for achieve valuable drugs leads.Recent years, pharmaceutical research into natural products has declined on the grounds of isolation of similar metabolites and high-throughput screening of synthetic products.On the other hand, resistant strains of pathogens are increasingly prevalent in hospitals and in the community.New diseases is pressing need to develop new drugs, but progress in developing them has been slow.Therefore, particularly the emergence of health issues suggests that the discovery of new scaffolds such as cytarabine (Ara-c), vidarabine (Vira-A1) and salinosporamide A should be a priority.New technologies provide smart screening methods to discover new natural drugs from untapped biological resources.Especially advances in rapid genetic sequencing, coupled with manipulation of biosynthetic pathways, may provide a vast resource potential for the discovery of new pharmaceuticals.These technological advances encourage renewed interest in natural products and the natural drug discovery.In this review, we focused on marine metabolites also bring the marine chemical diversity up to its therapeutic potential, while it is offering an extremely rich resource for novel compounds.