An attempt to predict daily erythrocyte lithium fluctuations
Articles > Article · 1995
Authors: Özlem SÖĞÜT, C Yalcinkaya, R Saygili, I Tuglular, A Kayali
European Journal of Drug Metabolism and Pharmacokinetics, Journal Indexed in SCI Expanded, International, 1995, vol 20, pp 271-274
DOI: 10.1007/bf03190243
Summary
Erythrocyte lithium concentration, which is a better predictor of brain lithium levels than plasma lithium concentrations, possesses the disadvantage of precise hourly determination following the last intake. The variability in RBC lithium accumulation increases as the extracellular lithium concentration increases. This increase is also time dependent and it would be very useful if the pharmacokinetic rate constant were known. Unfortunately, low lithium levels do not allow measurements within confidence intervals.