Novel magnesium and zinc porphyrazines containing galactose moieties: Synthesis via click reaction and characterization
Makaleler > Tam Makale · 2016
Yazarlar: Yasemin Baygu, Burak YILDIZ, Nilgun Kabay, Yasar Gok
INORGANIC CHEMISTRY COMMUNICATIONS, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2016, cilt 71, ss 35-40
DOI: 10.1016/j.inoche.2016.07.001
Özet
In this study, galactose conjugated new magnesium and zinc porphyrazines were synthesized by the cyclotetramerization reaction of 2,3-bis[1-(2,2,7,7-tetramethyltetra-hydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5,methyl)-1H-[1,2,3]triazol-4-yl methylsulfanyl]-but 2-enedinitrile. This substituted dicyano compound was prepared via two different routes. One started from cis-1,2-dicyano-1,2-ethylenedithiolate disodium, [1-(2, 2, 7,7-tetramethyltetrahydrobis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl-methyl)-1H-[1,2,3]triazo-1-4-yllmethanol and ended in a multi -step reaction sequence via Click procedures. The other reaction was between 5-azidomethyl-2,2,7,7-tetramethyltetrahydro-bis[1,3]clioxolo[4,5-b;4',5'-d]pyran and (2Z)-2,3-bis(prop-2-yl-1-yl-thio)but-2-enedinitrile. A very soluble galactose linked magnesium porphyrazine derivative in common polar solvents and water was achieved by the deprotected isopropylidene groups in TFA and water media. It is first time, zinc porphyrazine complex has been achieved at one-step reaction by using Zn(BuO)(2) as template agent. The new compounds have been characterized by a combination of elemental analysis, H-1, C-13 NMR, IR, UV-vis and MS spectral data. (C) 2016 Elsevier B.V. All rights reserved.