Enhanced Novel Object Recognition and Spatial Memory in Rats Selectively Bred for High Nicotine Preference

Makaleler > Tam Makale · 2024

Yazarlar: Ayşegül KESER, Ramazan Can GÖKMEN, Oğuz GÖZEN, Burcu BALKAN, Ersin Oğuz KOYLU

BRAIN SCIENCES, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2024, cilt 14, ss 1-15

DOI: 10.3390/brainsci14050427

Özet

<p>This&nbsp;study&nbsp;examined&nbsp;the&nbsp;influence&nbsp;of&nbsp;genetic&nbsp;background&nbsp;on&nbsp;cognitive&nbsp;performance&nbsp;in&nbsp;a&nbsp;selectively&nbsp;bred&nbsp;high&nbsp;nicotine-preferring&nbsp;(NP)&nbsp;rat&nbsp;line.&nbsp;Using&nbsp;the&nbsp;novel&nbsp;object&nbsp;recognition&nbsp;(NOR),&nbsp;novel&nbsp;location&nbsp;recognition&nbsp;(NLR),&nbsp;and&nbsp;Morris&nbsp;water&nbsp;maze&nbsp;(MWM)&nbsp;tests,&nbsp;we&nbsp;evaluated&nbsp;object&nbsp;memory,&nbsp;spatial&nbsp;memory,&nbsp;and&nbsp;spatial&nbsp;navigation&nbsp;in&nbsp;nicotine-naive&nbsp;NP&nbsp;rats&nbsp;compared&nbsp;to&nbsp;controls.&nbsp;Our&nbsp;results&nbsp;demonstrate&nbsp;that&nbsp;in&nbsp;the&nbsp;NOR&nbsp;test,&nbsp;both&nbsp;male&nbsp;and&nbsp;female&nbsp;NP&nbsp;rats&nbsp;spent&nbsp;more&nbsp;time&nbsp;exploring&nbsp;the&nbsp;novel&nbsp;object&nbsp;(higher&nbsp;discrimination&nbsp;index)&nbsp;compared&nbsp;to&nbsp;sex-matched&nbsp;controls.&nbsp;In&nbsp;the&nbsp;NLR,&nbsp;the&nbsp;discrimination&nbsp;index&nbsp;differed&nbsp;significantly&nbsp;from&nbsp;zero&nbsp;chance&nbsp;(no&nbsp;preference)&nbsp;in&nbsp;both&nbsp;NP&nbsp;males&nbsp;and&nbsp;females&nbsp;but&nbsp;not&nbsp;in&nbsp;controls,&nbsp;indicating&nbsp;enhanced&nbsp;spatial&nbsp;memory&nbsp;in&nbsp;the&nbsp;NP&nbsp;line.&nbsp;During&nbsp;MWM&nbsp;acquisition,&nbsp;the&nbsp;NP&nbsp;groups&nbsp;and&nbsp;control&nbsp;males&nbsp;took&nbsp;a&nbsp;shorter&nbsp;path&nbsp;to&nbsp;reach&nbsp;the&nbsp;platform&nbsp;compared&nbsp;to&nbsp;control&nbsp;females.&nbsp;On&nbsp;the&nbsp;probe&nbsp;trial,&nbsp;the&nbsp;distance&nbsp;traveled&nbsp;in&nbsp;the&nbsp;target&nbsp;quadrant&nbsp;was&nbsp;longer&nbsp;for&nbsp;NP&nbsp;males&nbsp;and&nbsp;females&nbsp;compared&nbsp;to&nbsp;their&nbsp;respective&nbsp;controls,&nbsp;suggesting&nbsp;enhanced&nbsp;spatial&nbsp;navigation&nbsp;and&nbsp;learning&nbsp;in&nbsp;the&nbsp;NP&nbsp;rats.&nbsp;The&nbsp;interesting&nbsp;preference&nbsp;for&nbsp;novel&nbsp;objects&nbsp;and&nbsp;locations&nbsp;displayed&nbsp;by&nbsp;NP&nbsp;rats&nbsp;may&nbsp;indicate&nbsp;a&nbsp;potential&nbsp;novelty-seeking&nbsp;phenotype&nbsp;in&nbsp;this&nbsp;line.&nbsp;These&nbsp;results&nbsp;highlight&nbsp;the&nbsp;complex&nbsp;interplay&nbsp;between&nbsp;genetic&nbsp;factors,&nbsp;cognitive&nbsp;function,&nbsp;and&nbsp;nicotine&nbsp;preference.</p>

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