Synthesis, characterization and tyrosinase inhibitory properties of benzimidazole derivatives
Articles > Article · 2014
Authors: Mert Olgun Karatas, Bulent Alici, Engin Çetinkaya, Çiǧdem Bilen, Nahit Gençer, Oktay Arslan
Russian Journal of Bioorganic Chemistry, International, WoS, 2014, vol 40, pp 461-466
DOI: 10.1134/s1068162014040049
Summary
1-Alkylbenzimidazole and 1,3-dialkyl benzimidazolium salts were synthesized and characterized by the data of IR, 1H NMR, 13C NMR spectra and elemental analyses. These compounds were investigated as tyrosinase inhibitors. Tyrosinase has been purified from banana by affinity chromatography on a Sepharose 4B gel conjugated with L-tyrosine-p-aminobenzoic acid. All the synthesized compounds inhibited the tyrosinase activity. Among the compounds studied, 1,4-di(1H-benzo[d]imidazol-1-yl)butane was found to be the most active tyrosinase inhibitor (IC50 0.31 mM).