Small cell neuroendocrine carcinoma of the thymus complicated by Cushing's syndrome - Report of a 58-year-old woman with a 3-year history of hypertension
Articles > Article · 2001
Authors: Mine HEKİMGİL, F HAMULU, UFUK CAGIRICI, BÜLENT KARABULUT, Ahmet Gökhan ÖZGEN, S SOYDAN, CENGİZ YILMAZ
PATHOLOGY RESEARCH AND PRACTICE, Journal Indexed in SCI Expanded, International, 2001, vol 197, pp 129-133
DOI: 10.1016/s0344-0338(04)70023-0
Summary
A 58-year-old woman with a history of Cushing's syndrome for three years presented with a mediastinal mass and received the diagnosis of small cell neuroendocrine carcinoma of the thymus invading the pericardium. On immunohistochemical study, the neoplastic cells reacted with antibodies against cytokeratin, epithelial membrane antigen, neuron-specific enolase, chromogranin, synaptophysin, and ACTH. Clinicopathologic findings of this rare case of ectopic adrenocorticotropic hormone (ACTH) syndrome are discussed with a literature review.