Synthesis, characterization and antimicrobial studies of new chiral amide-Schiff base derivatives
Makaleler > Tam Makale · 2020
Yazarlar: Seda YÜKSEKDANACI, Demet ASTLEY, İhsan YAŞA
Hacettepe Journal of Biology and Chemistry, Uluslararası, 2020, cilt 48, ss 33-39
DOI: 10.15671/hjbc.520248
Özet
In this study, new chiral Schiff bases (3-9) obtained from the reaction of chiral amide derivatives with different substituted aromatic aldehyde were synthesized. All synthesized compounds structures were characterized by FTIR, 1H-NMR, 13C-NMR and elemental analysis. All of the new synthesized compounds were tested in vitro against Staphylococcus aureus, Bacillus cereus, Escherichia coli, Salmonella thyphimirium, Klebsiella pneumoniae, Enterococcus faecalis, Pseudomonas aeruginosa, Candida albicans for their antibacterial and antifungal activities. All compounds have shown moderate to good antibacterial activity against Gram-positive and Gram-negative bacteria. Among the compounds tested compound 7 showed most potent inhibitory action against test organisms.