Dyslipidemia Prevalence in non-Obese non-Diabetic Patients with Obstructive Sleep APNEA: Does Sex Matter?
Conference paper > Summary Text
Authors: Özen KAÇMAZ BAŞOĞLU, M S Taşbakan, M Kayikcioglu
04.01 - Sleep science - basic and translational, , , International, Summary Text, pp 797-797
DOI: 10.1183/13993003.congress-2022.797
Summary
Background and objective: Several studies have shown impaired lipid profile in obstructive sleep apnea (OSA). Herein, we aimed to examine the lipid profile of non-diabetic and non-obese OSA patients and define the possible effects of age and sex. Methods: We retrospectively evaluated 2907 consecutive adults who has undergone polysomnography. A total of 2022 patients were excluded due to obesity (BMI>30kg/m2), diabetes, untreated hypothyroidism, using lipid lowering drugs, or missing sleep data. Results: Out of 882 patients (74.8% male, aged 46.8±12.2 year), included in the study, 70.1% had OSA. The proportions of patients with atherogenic dyslipidemia, hypercholesterolemia, and high non-HDL-cholesterol levels (>160 mg/dL) were significantly higher in OSA than non-OSA subjects. In multivariate analysis, the rate of hypercholesterolemia increased with severity of OSA (p=0.049), sleep time with oxygen saturation <90% (p=0.041), and age (p<0.001), besides, high non-HDL-cholesterol levels increased with OSA severity (p=0.006) and age (p=0.013) in female OSA patients, not in males. Conclusion: We showed that after excluding confounding obesity and diabetes, lipid profile including total cholesterol, LDL-cholesterol, non-HDL-cholesterol, and triglycerides is impaired in association with the severity of OSA. However, the association between dyslipidemia and OSA were only significant in women, not in men.