Degradation and gastrointestinal stability of nitrofurantoin in acidic and alkaline media
Articles > Article · 1993
Authors: Gökhan Ertan, Hatice Yeşim KARASULU, Tamer Güneri
International Journal of Pharmaceutics, Journal Indexed in SCI Expanded, International, Scopus, 1993, vol 96, pp 243-248
DOI: 10.1016/0378-5173(93)90233-6
Summary
The degradation of nitrofurantoin in acidic (pH 1.2) and alkaline (pH 10) solutions at 100°C was performed. Decomposition of the drug was faster under alkaline conditions than under acidic conditions. The major degradation product was isolated from the alkaline solution by column chromatographic separation using silica gel as adsorbant and was further purified by preparative thin-layer chromatography. The structure of this product was determined as 2-(5-nitro-2-furfurylidene) hydrazine acetate by the use of relevant UV, IR and 1H-NMR spectra. Degradation kinetics were evaluated; the reaction rate constants (k day-1) and chemical half-lives (t 1 2) were calculated depending on the first-order kinetics. Moreover, the stability of pure nitrofurantoin and of its commercial drug form in simulated gastric and intestinal media were investigated. © 1993.