Effects of Low-Intensity Shock Wave Therapy on Erectile Function and Penile Vascular Parameters in Men with Erectile Dysfunction: A Systematic Review and Meta-Analysis of Randomized Controlled Studies
Makaleler > Derleme · 2026
Yazarlar: Selahittin Cayan, Germar Michael Pinggera, Hiva Alipour, Rupin Shah, Bahadır Şahin, Ahmet Barış ALTAY, Taymour Mostafa, Fotios Dimitriadis, Fereshteh Dardmeh, Naveen Kumar, Diana Carolina Angel Alarcon, Noor Fathalla, Nadia Sheibak, Sk. Mizanur Rahman, Adel Gouri, Jose Moreno - Sepulveda, Salima Daoud, Christina Anagnostopoulou, Aleksei Ryzhkov, Tuncay Toprak, Mohamed Arafa, Erman Ceyhan, Ayman Rashed, Ayad Palani, Edoardo Pescatori, Manaf Al Hashimi, Kareim Khalafalla, Rossella Cannarella, Marco Falcone, Eric Chung, Ashok Agarwal
The World Journal of Men's Health, Uluslararası, Wos, 2026, cilt 44
DOI: 10.5534/wjmh.250266
Özet
PURPOSE: This systematic review and meta-analysis of randomized controlled trials evaluated the effects of low-intensity shock wave therapy (LiSWT) on erectile function (EF) and penile vascular parameters in men with erectile dysfunction (ED), compared with controls receiving sham or no treatment. MATERIALS AND METHODS: A systematic search of Scopus, PubMed, and Cochrane databases identified studies assessing LiSWT in men with ED. Primary outcomes were changes in the International Index of Erectile Function (IIEF)-5 and the IIEF-EF domain scores. Secondary outcomes included erection hardness score (EHS), sexual encounter profile (SEP) diary Q2 and Q3, global assessment question (GAQ) scores, and penile Doppler ultrasound parameters-peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI). Changes from baseline to the end of follow-up were compared between LiSWT and control groups. RESULTS: Of 527 retrieved articles, 12 met inclusion criteria. Pooled analysis demonstrated significantly greater improvements in the LiSWT group for IIEF-5 (standardized mean difference [SMD], 1.19; 95% confidence interval [CI], 0.47-1.91; p=0.001) and IIEF-EF (SMD, 1.24; 95% CI, 1.02-1.45; p<0.001) scores compared with controls. No significant differences were found for EHS (p=0.698), SEP-Q2 (p=0.934), SEP-Q3 (p=0.985), GAQ (p=0.993), and penile Doppler ultrasound parameters, including PSV (p=0.855), EDV (p=0.995), or RI (p=0.818). CONCLUSIONS: LiSWT provides modest improvements in IIEF scores but fails to produce significant changes in other functional or vascular parameters. These findings suggest that while LiSWT may offer some benefit, the clinical relevance is limited for most patients. Current evidence does not support its routine inclusion in ED treatment algorithms. Future research should focus on identifying patient subgroups most likely to experience significant and sustained improvements from this therapy.