Late endocrine side effects in children with acute leukemia
Articles > Article · 2007
Authors: Mustafa Büyükavci, Nazan Çetingül, Şükran DARCAN, Mehmet KANTAR, Ramazan Kaan KAVAKLI
TURKISH JOURNAL OF HEMATOLOGY, Journal Indexed in SCI Expanded, International, Scopus, 2007, vol 24, pp 8-13
Summary
This study was carried out in 28 patients (10 female, 18 male) diagnosed with acute leukemia, and aimed to investigate the abnormalities of endocrine system. Twenty-five of 28 patients were acute lymphoblastic leukemia and 3 were acute non-lymphocytic leukemia. Sixteen children were treated using BFM-90 chemotherapy protocol, and the rest with various regimens. Two patients were exposed to 12-13 Gy of total body irradiation followed by bone marrow transplantation. All patients were in remission at least five years. One (3%) of 28 patients had short stature and 4 (14%) had obesity. Pubertal status was retarded in 2 (7%) patients. Glucose intolerance, secondary hypothyroidism and hypergonadotropic hypogonadism were detected in 2, 1 and 2 patients, respectively. TSH response to TRH test was exaggerated in 1 and blunted in 3 patients. © Turkish Society of Hematology.